Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing.This work will allow me to identify new drug targets that may be used to improve treatment strategies for AML in the elderly. M y research goal is to investigate the effects of the ageing bone marrow microevironment in the prognosis of acute myeloid leukaemia (AML). I will specifically examine how the ageing microenvironment influences Leukemic Stem Cells behaviour contributing to their increased chemo-resistance and/or disease re-initiation after therapeutic intervention in elderly. In July 2019 I was awarded a prestigious Kay Kendall Leukaemia Fund Intermediate Fellowship for three years at the Weatherall Institute of Molecular Medicine. In November 2015 I joined Professor Claus Nerlov group in the MRC Molecular Haematology Unit at the WIMM. Over the last four years, my research has been focused mainly on understanding the cellular and molecular mechanisms underlying the decline of erythropoiesis during ageing, determining the contributions to this process of both the haematopoietic and stromal component of the haematopoietic system. There, I developed a special interest in the new powerful genome editing CRISPR/Cas9 tool that I used to correct the ASXL1 homozygous nonsense mutation present in the CML cell line KBM5, resulting in protein re-expression with restored normal function. I then moved to the University of Oxford, where I joined Professor Jacqueline Boultwood group (Bloodwise Molecular Haematology Unit/ Nuffield Division of Clinical Laboratory Sciences) as a postdoctoral scientist to elucidate the function of ASXL1, a gene commonly mutated in myeloid malignancies including CML. By using exome sequencing approach, we discovered SETBP1 as a novel oncogene and identified specific mutations of this gene in patients affected by aCML. During my PhD I worked under the supervision of Professor Carlo Gambacorti-Passerini and my research was focused on the characterization of atypical Chronic Myeloid Leukemia (aCML), a heterogeneous disorder belonging to the group of myelodysplastic/myeloproliferative (MDS/MPN) syndromes. I obtained my PhD in Experimental Haematology from the University of Milan in 2014. There is so much to see in Valetta, and even though the city is so very small, it is definitely worth a visit.I am a KKLF Intermediate Research Fellow based in the Professor Claus Nerlov group in the MRC Molecular Haematology Unit at the Weatherall Institute of Molecular Medicine (WIMM). – Visit the Casa Rocca Piccola to learn about the history of Malta, and see how the Grand Master used to live – Watch one of the shows in Manoel Theatre – Take the ferry over to Sliema and do a harbour cruise – don’t forget your camera for the best views of Valletta – Visit the Upper Barrakka Gardens at noon to see the cannon being fired, or in the late afternoon to watch cruise ships leave the harbour – If you would like to experience the wonderful sunrise with views over the harbour, you should go to the bastion of St. – Have a coffee in the great Café Cordina and enjoy the great atmosphere There are a few things that you should do if you are ever in Valletta: Since many of the towns are right next to each other you will also not feel like you are in small town. The buses can take you quickly to any other part of the island. You will not have to be afraid to get stranded in Valletta. Since Valletta is not very large you can easily reach everything on foot. The city is surrounded by various forts and fortifications. Valletta is also perfect for history fans. Especially when doing a day trip you can see a lot of this beautiful city. The capital of Malta is very much alive and one of the centres of tourism. Paul’s Co Cathedral in the heart of the city. You can admire one of the most beautiful interior designs of churches in the St. You can find beautiful cafes and wine bars that are surrounded by baroque architecture. The capital is one of the biggest tourist attractions in Malta. And this is the reason why Valletta was declared as a UNESCO World Heritage site in 1980. It is safe to say that this tiny city is a living monument of architecture. Maybe you did not know it yet, but Valletta is the smallest capital in Europe. In today’s post I would like to talk a little bit about the capital of Malta.
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